Pipeline


Companies
Eveliqure is a clinical-stage bio-technology company developing an oral broad-coverage vaccine against diarrhoeal diseases for travelers and young children living in disease endemic regions of the world.
The clinical stage vaccine ShigETEC - targeting Shigella and entero-toxigenic E. coli (ETEC) infections - is being evaluated in Phase 1b trial with small children in Bangladesh and in a human infectious model (Phase 2 efficacy study) in the US.
CALYXHA is an innovative biotech company developing novel small molecule anti-inflammatory drugs.
CALYXHA’s lead drug candidate targets multiple inflammatory diseases, with robust efficacy data in inhalative asthma models. The Company is currently in preclinical development GMP manufacture) and ready to enter IND enabling studies.
TAG Therapeutics is a young start-up growing out from CEBINA’s acceleration program, DanubeLabs.
TAG’s highly innovative ASO-based technology is addressing telomere pathologies, and addresses both rare genetic diseases and age-related disorders, Idiopathic Pulmonary Fibrosis (IPF) being the first clinical target.
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Internal innovative projects
The antihistamine azelastine as broad antiviral approach
The antihistamine azelastine as broad antiviral approach
As a short-term response to the COVID-19 pandemic, CEBINA, in collaboration with Professor Robert Konrat, a renowned structural biologist (Department of Structural and Computational Biology, University of Vienna, Austria) applied a novel computational approach to identify compounds to be repurposed as anti-COVID-19 drugs (Konrat at al, 2022). This approach led to the identification of azelastine, a generic anti-histamine medication available as nasal spray. CEBINA entered in partnership with URSAPHARM Arzneimittel GmbH to develop the azelastine nasal spray as anti-COVID-19 remedy. CEBINA scientists proved a broad antiviral activity for azelastine, against influenza, RSV, and seasonal coronaviruses (Fischhuber et al, 2023).
The clinical efficacy of azelastine has been shown in three independent Phase 2 clinical trials. Read more.